What Biologic Is Best for Your Condition?
Condition-by-condition comparison of FDA-approved biologics — with clinical context to help you have an informed conversation with your prescriber.
The best biologic depends on your specific condition, disease severity, prior treatment history, and insurance coverage. BiologicHealthPlus pharmacists can review your coverage and help your prescriber identify the most effective and affordable option for you.
Best Biologics by Condition
What biologic is best for psoriatic arthritis?
For psoriatic arthritis, highly effective biologics include Cosentyx (secukinumab), Tremfya (guselkumab), Humira (adalimumab), Rinvoq (upadacitinib), Bimzelx (bimekizumab), Enbrel (etanercept), and Remicade (infliximab). Your rheumatologist selects based on joint vs. skin burden.
What biologic is best for psoriasis?
For plaque psoriasis, Skyrizi (risankizumab) and Tremfya (guselkumab) achieve PASI 90 or better in most patients in clinical trials. Cosentyx, Bimzelx, Humira, and Ilumya are also highly effective. Response rates vary by patient.
What biologic is best for rheumatoid arthritis?
For RA, Humira (adalimumab), Rinvoq (upadacitinib), and Orencia (abatacept) are among the most widely used. Actemra and Kevzara are preferred for certain RA phenotypes. Your rheumatologist determines the best choice based on prior treatment history.
What biologic is used for lupus?
FDA-approved biologics for lupus (SLE) include Benlysta (belimumab) and Saphnelo (anifrolumab). BiologicHealthPlus can assist with insurance coverage and copay assistance for both medications.
What biologic is best for ankylosing spondylitis?
For ankylosing spondylitis (AS), Cosentyx (secukinumab) and Rinvoq (upadacitinib) show strong efficacy. Humira, Enbrel, Remicade, Cimzia, and Simponi are also approved for AS.
What biologic is best for ulcerative colitis?
For UC, Stelara (ustekinumab) and Entyvio (vedolizumab) have strong efficacy and safety profiles. Omvoh (mirikizumab) is a newer option with high remission rates. Humira, Remicade, and Simponi are also established options.
What biologic is used for hidradenitis suppurativa?
For HS, FDA-approved biologics include Humira (adalimumab), Cosentyx (secukinumab), and Bimzelx (bimekizumab). Bimzelx is the newest approval for HS with strong clinical trial data.
What biologic is safest?
No single biologic is 'safest' for all patients. Safety depends on your specific medical history, other medications, infection history, and disease. Your prescriber determines the most appropriate biologic after reviewing your full clinical profile.
What is considered a biologic?
A biologic (or biological medicine) is a medication derived from living organisms using biotechnology. Unlike chemical drugs, biologics are large protein molecules that target specific components of the immune system. FDA-approved biologics include monoclonal antibodies, fusion proteins, and JAK inhibitors.
What biologic works best for Crohn's disease?
For Crohn's disease, Skyrizi (risankizumab) has shown strong induction and maintenance remission rates in clinical trials. Stelara, Humira, Remicade, and Entyvio are also highly effective. Cimzia and Rinvoq are additional options.
Have a question about your biologic?
Speak with a BiologicHealthPlus pharmacist 24/7Detailed Answers
For psoriatic arthritis, highly effective biologics include Cosentyx (secukinumab), Tremfya (guselkumab), Humira (adalimumab), Rinvoq (upadacitinib), Bimzelx (bimekizumab), Enbrel (etanercept), and Remicade (infliximab). Your rheumatologist selects based on joint vs. skin burden.
For plaque psoriasis, Skyrizi (risankizumab) and Tremfya (guselkumab) achieve PASI 90 or better in most patients in clinical trials. Cosentyx, Bimzelx, Humira, and Ilumya are also highly effective. Response rates vary by patient.
For RA, Humira (adalimumab), Rinvoq (upadacitinib), and Orencia (abatacept) are among the most widely used. Actemra and Kevzara are preferred for certain RA phenotypes. Your rheumatologist determines the best choice based on prior treatment history.
FDA-approved biologics for lupus (SLE) include Benlysta (belimumab) and Saphnelo (anifrolumab). BiologicHealthPlus can assist with insurance coverage and copay assistance for both medications.
For ankylosing spondylitis (AS), Cosentyx (secukinumab) and Rinvoq (upadacitinib) show strong efficacy. Humira, Enbrel, Remicade, Cimzia, and Simponi are also approved for AS.
For UC, Stelara (ustekinumab) and Entyvio (vedolizumab) have strong efficacy and safety profiles. Omvoh (mirikizumab) is a newer option with high remission rates. Humira, Remicade, and Simponi are also established options.
For HS, FDA-approved biologics include Humira (adalimumab), Cosentyx (secukinumab), and Bimzelx (bimekizumab). Bimzelx is the newest approval for HS with strong clinical trial data.
No single biologic is 'safest' for all patients. Safety depends on your specific medical history, other medications, infection history, and disease. Your prescriber determines the most appropriate biologic after reviewing your full clinical profile.
A biologic (or biological medicine) is a medication derived from living organisms using biotechnology. Unlike chemical drugs, biologics are large protein molecules that target specific components of the immune system. FDA-approved biologics include monoclonal antibodies, fusion proteins, and JAK inhibitors.
For Crohn's disease, Skyrizi (risankizumab) has shown strong induction and maintenance remission rates in clinical trials. Stelara, Humira, Remicade, and Entyvio are also highly effective. Cimzia and Rinvoq are additional options.