Skyrizi (Risankizumab)
AbbVie · IL-23 Inhibitor · Subcutaneous injection
💊 Cash / List Price (without insurance)
$23,838/dose
WAC · Manufacturer published list price
🛡️ With Insurance + Copay Card
$0/mo
SkyCare360 · Most insured patients
🆓 Uninsured / PAP Eligible
Free
Income-based · SkyCare360
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Skyrizi at a Glance
- Generic: Risankizumab
- Manufacturer: AbbVie
- Mechanism: IL-23 Inhibitor
- Drug Class: Biologic – Monoclonal Antibody
- Route: Subcutaneous injection
- Frequency: Every 12 weeks (maintenance)
- Savings Program: SkyCare360
About Skyrizi
Skyrizi (risankizumab) is an IL-23 inhibitor manufactured by AbbVie. It selectively inhibits the IL-23 pathway, which plays a key role in inflammatory skin and bowel diseases.
FDA-Approved Indications
- Plaque Psoriasis
- Psoriatic Arthritis
- Crohn's Disease
- Ulcerative Colitis
💰 $0–$35/month for most insured patients
BiologicHealthPlus enrolls every patient in the SkyCare360 program and all other available savings at no charge. Contact us to see what you qualify for.
Frequently Asked Questions
Skyrizi is FDA-approved for moderate-to-severe plaque psoriasis, active psoriatic arthritis, moderately to severely active Crohn's disease, and moderately to severely active ulcerative colitis.
Through the SkyCare360 program, most eligible insured patients pay $0/month. BiologicHealthPlus enrolls all patients in available savings programs.
For psoriasis and psoriatic arthritis, Skyrizi is typically injected every 12 weeks after initial dosing. Dosing schedules for Crohn's disease and UC may differ.
Comparisons
Skyrizi and Humira are both used in inflammatory conditions but differ in mechanism, dosing, administration route, and approved indications. Your healthcare provider can help determine which medication is most appropriate for your specific situation.
Skyrizi and Cosentyx are both used in inflammatory conditions but differ in mechanism, dosing, administration route, and approved indications. Your healthcare provider can help determine which medication is most appropriate for your specific situation.
Skyrizi and Tremfya are both used in inflammatory conditions but differ in mechanism, dosing, administration route, and approved indications. Your healthcare provider can help determine which medication is most appropriate for your specific situation.
Skyrizi and Taltz are both used in inflammatory conditions but differ in mechanism, dosing, administration route, and approved indications. Your healthcare provider can help determine which medication is most appropriate for your specific situation.
Skyrizi and Stelara are both used in inflammatory conditions but differ in mechanism, dosing, administration route, and approved indications. Your healthcare provider can help determine which medication is most appropriate for your specific situation.
Skyrizi and Rinvoq are both used in inflammatory conditions but differ in mechanism, dosing, administration route, and approved indications. Your healthcare provider can help determine which medication is most appropriate for your specific situation.
Skyrizi and Bimzelx are both used in inflammatory conditions but differ in mechanism, dosing, administration route, and approved indications. Your healthcare provider can help determine which medication is most appropriate for your specific situation.
Skyrizi and Ilumya are both used in inflammatory conditions but differ in mechanism, dosing, administration route, and approved indications. Your healthcare provider can help determine which medication is most appropriate for your specific situation.
Skyrizi and Enbrel are both used in inflammatory conditions but differ in mechanism, dosing, administration route, and approved indications. Your healthcare provider can help determine which medication is most appropriate for your specific situation.
Skyrizi and Cimzia are both used in inflammatory conditions but differ in mechanism, dosing, administration route, and approved indications. Your healthcare provider can help determine which medication is most appropriate for your specific situation.
Lifestyle
Moderate alcohol consumption is not specifically prohibited with Skyrizi, but alcohol can affect your immune system and overall health. Discuss your habits with your healthcare provider.
Many patients continue regular exercise while taking Skyrizi. Staying active may support your overall health. Ask your provider about any activity restrictions specific to your condition.
No specific dietary restrictions are required for Skyrizi. A balanced, nutritious diet supports immune health and may complement your treatment. Consult your provider if you have concerns.
Some antibiotics may interact with immunosuppressive medications. Always inform your prescriber and pharmacist of any antibiotics you are taking while on Skyrizi.
Certain supplements may interact with Skyrizi or affect your immune response. Tell your healthcare provider and pharmacist about all supplements you take.
Some herbal products can interact with biologics or alter immune function. Disclose all herbal medicines to your provider before starting or while taking Skyrizi.
Some patients report changes in sleep while on biologic therapy. If you experience sleep disturbances while taking Skyrizi, discuss them with your healthcare provider.
Some patients notice mood changes while on biologic therapy. Controlling your underlying condition may also affect how you feel. Talk to your provider if you notice mood or mental health changes.
Live vaccines are generally not recommended while taking Skyrizi. Speak with your healthcare provider about which vaccines are safe and appropriate for you before receiving any immunizations.
Not smoking, maintaining a healthy weight, staying physically active, following your prescribed schedule, and attending regular check-ups may all support better outcomes with Skyrizi.
Travel & Storage
Skyrizi should be stored in the refrigerator at 36°F to 46°F (2°C to 8°C). Keep it in its original carton and protected from light. Do not shake.
Yes. Skyrizi must be refrigerated. It should not be exposed to temperatures outside the recommended range for extended periods.
No. Skyrizi should not be frozen. If it freezes, do not use it. Contact your pharmacist for guidance.
Skyrizi can generally be kept at room temperature up to 77°F (25°C) for a limited period when traveling. Check the prescribing information or ask your pharmacist for the specific time limit.
Yes. Use an insulated travel cooler to keep Skyrizi at the correct temperature during transit. Plan your injections around your travel schedule and carry extra supplies.
Yes. Injectable medications are permitted through airport security. Carry a letter from your prescriber and the original pharmacy label to avoid delays.
International shipping of biologic medications involves customs regulations and cold-chain requirements that vary by country. Contact your specialty pharmacy for guidance before any international shipment.
It is generally recommended to carry Skyrizi in your carry-on luggage to maintain temperature control and reduce the risk of loss or damage.
A signed letter from your prescriber explaining your medication is recommended, especially for international travel, to help you pass through customs and security without issues.
Do not use Skyrizi that has been improperly stored. Contact your specialty pharmacy immediately to report the issue and arrange a replacement shipment.
Patient Education
Review the administration instructions with your healthcare provider or pharmacist, confirm correct storage, and gather all supplies before your first dose. Know what to expect and who to call with questions.
Follow the instructions provided with your medication and any training given by your healthcare provider. Inject into an approved site, rotating locations each time. Contact your pharmacist if you have questions about technique.
Place used needles and syringes immediately into an FDA-cleared sharps disposal container. Do not place loose sharps in household trash. Follow local community guidelines for sharps disposal.
Your healthcare provider will determine which baseline tests are needed based on your history. Common pre-treatment screening may include blood counts and tests for certain infections such as tuberculosis and hepatitis.
Monitoring frequency depends on your condition and health status. Your provider will set an appropriate schedule for you.
Do not stop Skyrizi without consulting your healthcare provider. Stopping without medical guidance could affect your condition's management.
Contact your provider if you experience signs of infection, unusual reactions at the injection site, new or worsening symptoms, or any other concerns about your treatment.
Report any side effects to your healthcare provider promptly. For severe reactions such as difficulty breathing or swelling, seek emergency care immediately.
Your healthcare provider and pharmacist are the most reliable resources. The manufacturer's official website and FDA prescribing information also provide detailed clinical guidance.
Consider asking about expected benefits, potential risks, how long until you may see results, what to do if you miss a dose, and how Skyrizi interacts with other medications or vaccines you take.
Medical Disclaimer: This page is for informational purposes only and does not constitute medical advice. Always consult your prescribing physician or pharmacist before making any treatment decisions. BiologicHealthPlus is a licensed specialty pharmacy — not a medical practice.