Stelara (Ustekinumab)
Janssen · IL-12/23 Inhibitor · Subcutaneous injection / IV infusion (induction)
💊 Cash / List Price (without insurance)
$27,000–$31,000/mo
WAC · Manufacturer published list price
🛡️ With Insurance + Copay Card
$0–$35/mo
Janssen CarePath · Most insured patients
🆓 Uninsured / PAP Eligible
Free
Income-based · Janssen CarePath
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Stelara at a Glance
- Generic: Ustekinumab
- Manufacturer: Janssen
- Mechanism: IL-12/23 Inhibitor
- Drug Class: Biologic – Monoclonal Antibody
- Route: Subcutaneous injection / IV infusion (induction)
- Frequency: Every 12 weeks (maintenance)
- Savings Program: Janssen CarePath
About Stelara
Stelara (ustekinumab) is an IL-12/23 inhibitor manufactured by Janssen. It targets both the IL-12 and IL-23 pathways involved in autoimmune inflammatory diseases.
FDA-Approved Indications
- Plaque Psoriasis
- Psoriatic Arthritis
- Crohn's Disease
- Ulcerative Colitis
💰 $0–$35/month for most insured patients
BiologicHealthPlus enrolls every patient in the Janssen CarePath program and all other available savings at no charge. Contact us to see what you qualify for.
Frequently Asked Questions
Stelara is FDA-approved for moderate-to-severe plaque psoriasis, active psoriatic arthritis, moderately to severely active Crohn's disease, and moderately to severely active ulcerative colitis.
Through the Janssen CarePath savings program, most eligible insured patients pay $0–$35/month.
FDA-approved ustekinumab biosimilars have become available. Ask your pharmacist about current biosimilar options.
Injections & Administration
Follow the instructions provided with your medication and any training given by your healthcare provider. Inject subcutaneously into the recommended site, rotating locations each time. Contact your pharmacist or prescriber if you have questions about technique.
Used needles and syringes should be placed in an FDA-cleared sharps disposal container immediately after use. Do not throw loose needles in household trash. Follow your local community guidelines for sharps disposal.
Review the administration instructions with your healthcare provider or pharmacist, confirm the medication has been stored correctly, and ensure you have all necessary supplies. Ask your care team about what to expect and when to take your first dose.
Allowing the medication to reach room temperature before injecting, using a clean dry injection site, and relaxing the muscle in the area may help reduce discomfort. Speak with your pharmacist for additional tips.
Yes. Rotating injection sites is generally recommended to help reduce irritation. Common sites include the thigh, abdomen, and upper arm. Follow your healthcare provider's guidance on approved locations for your situation.
Contact your healthcare provider if you are ill before your scheduled injection. They can advise whether it is appropriate to administer the dose or wait until you have recovered.
If you have an active infection, contact your prescriber before taking your next dose. They will determine whether to delay your injection until the infection has resolved.
Certain vaccines may not be recommended while taking Stelara. Discuss your vaccination needs and schedule with your healthcare provider before receiving any vaccines.
Contact your doctor if you experience signs of infection, unusual reactions at the injection site, new or worsening symptoms, or any concerns about your treatment. Always reach out if something feels wrong.
Your healthcare provider and pharmacist are your best resources. You can also visit the manufacturer's official website or FDA-approved prescribing information for detailed clinical guidance.
Comparisons
Stelara and Humira are both used in inflammatory conditions but differ in mechanism, dosing, administration route, and approved indications. Your healthcare provider can help determine which medication is most appropriate for your specific situation.
Stelara and Cosentyx are both used in inflammatory conditions but differ in mechanism, dosing, administration route, and approved indications. Your healthcare provider can help determine which medication is most appropriate for your specific situation.
Stelara and Skyrizi are both used in inflammatory conditions but differ in mechanism, dosing, administration route, and approved indications. Your healthcare provider can help determine which medication is most appropriate for your specific situation.
Stelara and Tremfya are both used in inflammatory conditions but differ in mechanism, dosing, administration route, and approved indications. Your healthcare provider can help determine which medication is most appropriate for your specific situation.
Stelara and Taltz are both used in inflammatory conditions but differ in mechanism, dosing, administration route, and approved indications. Your healthcare provider can help determine which medication is most appropriate for your specific situation.
Stelara and Rinvoq are both used in inflammatory conditions but differ in mechanism, dosing, administration route, and approved indications. Your healthcare provider can help determine which medication is most appropriate for your specific situation.
Stelara and Remicade are both used in inflammatory conditions but differ in mechanism, dosing, administration route, and approved indications. Your healthcare provider can help determine which medication is most appropriate for your specific situation.
Stelara and Entyvio are both used in inflammatory conditions but differ in mechanism, dosing, administration route, and approved indications. Your healthcare provider can help determine which medication is most appropriate for your specific situation.
Stelara and Cimzia are both used in inflammatory conditions but differ in mechanism, dosing, administration route, and approved indications. Your healthcare provider can help determine which medication is most appropriate for your specific situation.
Stelara and Simponi are both used in inflammatory conditions but differ in mechanism, dosing, administration route, and approved indications. Your healthcare provider can help determine which medication is most appropriate for your specific situation.
Lifestyle
Moderate alcohol consumption is not specifically prohibited with Stelara, but alcohol can affect your immune system and overall health. Discuss your habits with your healthcare provider.
Many patients continue regular exercise while taking Stelara. Staying active may support your overall health. Ask your provider about any activity restrictions specific to your condition.
No specific dietary restrictions are required for Stelara. A balanced, nutritious diet supports immune health and may complement your treatment. Consult your provider if you have concerns.
Some antibiotics may interact with immunosuppressive medications. Always inform your prescriber and pharmacist of any antibiotics you are taking while on Stelara.
Certain supplements may interact with Stelara or affect your immune response. Tell your healthcare provider and pharmacist about all supplements you take.
Some herbal products can interact with biologics or alter immune function. Disclose all herbal medicines to your provider before starting or while taking Stelara.
Some patients report changes in sleep while on biologic therapy. If you experience sleep disturbances while taking Stelara, discuss them with your healthcare provider.
Some patients notice mood changes while on biologic therapy. Controlling your underlying condition may also affect how you feel. Talk to your provider if you notice mood or mental health changes.
Live vaccines are generally not recommended while taking Stelara. Speak with your healthcare provider about which vaccines are safe and appropriate for you before receiving any immunizations.
Not smoking, maintaining a healthy weight, staying physically active, following your prescribed schedule, and attending regular check-ups may all support better outcomes with Stelara.
Medical Disclaimer: This page is for informational purposes only and does not constitute medical advice. Always consult your prescribing physician or pharmacist before making any treatment decisions. BiologicHealthPlus is a licensed specialty pharmacy — not a medical practice.