Xeljanz (Tofacitinib)
Pfizer · JAK Inhibitor · Oral tablet
💊 Cash / List Price (without insurance)
$4,000–$5,000/mo
WAC · Manufacturer published list price
🛡️ With Insurance + Copay Card
$0–$5/mo
Pfizer RxPathways · Most insured patients
🆓 Uninsured / PAP Eligible
Free
Income-based · Pfizer RxPathways
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About Xeljanz (Tofacitinib)
Xeljanz (Tofacitinib) is a JAK Inhibitor manufactured by Pfizer. Xeljanz inhibits JAK1 and JAK3, blocking the signaling of multiple cytokines involved in immune activation and the inflammatory process.
⚠️ BLACK BOX WARNING
Serious infections, malignancies, thrombosis, MACE, and mortality. Not recommended for patients 50+ with at least one cardiovascular risk factor based on clinical trial data.
💰 $0–$5/month for most insured patients
BiologicHealthPlus enrolls every patient in the Pfizer RxPathways program and all other available savings at no charge. Contact us to verify what you qualify for.
How Long Does Xeljanz Take to Work?
Symptom improvement often begins within 2–4 weeks; maximum benefit typically seen within 3 months.
Xeljanz at a Glance
- Generic: Tofacitinib
- Manufacturer: Pfizer
- Drug Class: JAK Inhibitor
- Type: Targeted Synthetic DMARD – Oral Tablet
- Route: Oral tablet
- Frequency: Twice daily (IR) or once daily (XR)
- Savings: Pfizer RxPathways
- Storage: Room temperature (59°F–86°F / 15°C–30°C)
FDA-Approved Uses for Xeljanz
Xeljanz is FDA-approved to treat the following conditions:
Dosage & Administration
Typical Xeljanz Dosage
- Route: Oral tablet
- Frequency: Twice daily (IR) or once daily (XR)
- Common Dose: 5 mg twice daily or 11 mg (XR) once daily.
⚠️ Dosage varies by indication, age, and weight. Always follow your prescriber's instructions. Do not adjust your dose without medical guidance.
Storage & Cold-Chain Delivery
🌡️ Required Storage Temperature
Room temperature (59°F–86°F / 15°C–30°C)
Keep in original carton. Protect from light. Do not freeze or shake.
✈️ Traveling with Xeljanz
Store at room temperature
Use an insulated cooler. Carry prescriber letter. Keep in carry-on luggage.
🚚 Free Cold-Chain Delivery
BiologicHealthPlus ships Xeljanz in temperature-controlled packaging to all 50 states at no charge.
Learn about delivery →Required Monitoring
Tests & Monitoring for Xeljanz
- CBC before and during therapy
- Lipid panel 4–8 weeks after starting
- Liver function tests
- TB and hepatitis B screening
Your prescriber determines your monitoring schedule. BiologicHealthPlus coordinates with your provider's office on your behalf.
Insurance, Savings & Prior Authorization
🛡️ Commercial Insurance
Most commercially insured patients pay $0–$5/month through the Pfizer RxPathways program.
Insurance guide →🆓 Patient Assistance Program
Uninsured or income-eligible patients may receive Xeljanz free of charge through the Pfizer RxPathways PAP.
Check eligibility →🏥 Medicare & Medicaid
BiologicHealthPlus works with Medicare Part B, Part D, and Medicaid plans nationwide. We verify your benefits at no charge.
Verify coverage →✅ Prior Authorization — We Handle Everything at No Cost
BiologicHealthPlus files and manages prior authorizations for Xeljanz completely free. We appeal denials, work with your prescriber, and get your medication approved as fast as possible.
Learn about prior authorization →Xeljanz by Condition
Xeljanz (Tofacitinib) is FDA-approved for Rheumatoid Arthritis. Xeljanz inhibits JAK1 and JAK3, blocking the signaling of multiple cytokines involved in immune activation and the inflammatory process. Your prescriber will determine the appropriate dose and monitoring schedule based on your specific condition and health history. BiologicHealthPlus can assist with insurance verification, prior authorization, and free cold-chain delivery of Xeljanz for Rheumatoid Arthritis.
Xeljanz (Tofacitinib) is FDA-approved for Psoriatic Arthritis. Xeljanz inhibits JAK1 and JAK3, blocking the signaling of multiple cytokines involved in immune activation and the inflammatory process. Your prescriber will determine the appropriate dose and monitoring schedule based on your specific condition and health history. BiologicHealthPlus can assist with insurance verification, prior authorization, and free cold-chain delivery of Xeljanz for Psoriatic Arthritis.
Xeljanz (Tofacitinib) is FDA-approved for Ulcerative Colitis. Xeljanz inhibits JAK1 and JAK3, blocking the signaling of multiple cytokines involved in immune activation and the inflammatory process. Your prescriber will determine the appropriate dose and monitoring schedule based on your specific condition and health history. BiologicHealthPlus can assist with insurance verification, prior authorization, and free cold-chain delivery of Xeljanz for Ulcerative Colitis.
Xeljanz (Tofacitinib) is FDA-approved for Ankylosing Spondylitis. Xeljanz inhibits JAK1 and JAK3, blocking the signaling of multiple cytokines involved in immune activation and the inflammatory process. Your prescriber will determine the appropriate dose and monitoring schedule based on your specific condition and health history. BiologicHealthPlus can assist with insurance verification, prior authorization, and free cold-chain delivery of Xeljanz for Ankylosing Spondylitis.
Xeljanz (Tofacitinib) is FDA-approved for Polyarticular JIA. Xeljanz inhibits JAK1 and JAK3, blocking the signaling of multiple cytokines involved in immune activation and the inflammatory process. Your prescriber will determine the appropriate dose and monitoring schedule based on your specific condition and health history. BiologicHealthPlus can assist with insurance verification, prior authorization, and free cold-chain delivery of Xeljanz for Polyarticular JIA.
Frequently Asked Questions About Xeljanz
Xeljanz (Tofacitinib) is FDA-approved for: Rheumatoid Arthritis, Psoriatic Arthritis, Ulcerative Colitis, Ankylosing Spondylitis, Polyarticular JIA.
The cash list price for Xeljanz is approximately $4,000–$5,000/month. With commercial insurance and the Pfizer RxPathways program, most patients pay $0–$5/month. Uninsured or income-eligible patients may receive Xeljanz free through patient assistance programs. BiologicHealthPlus enrolls every patient in all available savings at no charge.
Xeljanz inhibits JAK1 and JAK3, blocking the signaling of multiple cytokines involved in immune activation and the inflammatory process.
Symptom improvement often begins within 2–4 weeks; maximum benefit typically seen within 3 months.
Xeljanz should be stored at Room temperature (59°F–86°F / 15°C–30°C). Store at room temperature. Keep in original carton, protect from light, and do not freeze or shake.
Yes. Use an insulated travel cooler to maintain the required temperature during transit. Carry a letter from your prescriber explaining your medication, and keep Xeljanz in your carry-on luggage to maintain temperature control and reduce the risk of loss or damage.
Xeljanz may be covered under Medicare Part B or Part D depending on how it is administered and your specific plan. BiologicHealthPlus works with Medicare plans nationwide and will verify your coverage and help you understand your out-of-pocket costs.
Most insurance plans require prior authorization for Xeljanz. BiologicHealthPlus handles the entire prior authorization process at no cost — we submit the request, gather clinical documentation, and appeal any denials on your behalf.
No FDA-approved biosimilars are currently available for Xeljanz. BiologicHealthPlus will keep you informed as new options become available.
The Pfizer RxPathways program is a manufacturer-sponsored savings program for Xeljanz. Most commercially insured patients qualify to pay $0–$5/month. BiologicHealthPlus enrolls every eligible patient in this and all other available savings programs at no additional charge.
Do not stop taking Xeljanz without consulting your healthcare provider. Stopping suddenly may cause your condition to worsen or symptoms to return. Your provider will create a safe transition plan if you need to discontinue treatment.
Transferring to BiologicHealthPlus is simple. Upload your prescription via our website, WhatsApp, or email. We coordinate with your doctor's office, verify your insurance, enroll you in the Pfizer RxPathways program, and arrange free cold-chain delivery — usually within 1–2 business days.
Live vaccines are generally not recommended while taking immunosuppressive medications like Xeljanz. Inactivated vaccines may be safe. Always speak with your healthcare provider about which vaccines are appropriate before receiving any immunization.
How Xeljanz Compares to Other Medications
Xeljanz and Rinvoq are both used in autoimmune or inflammatory conditions but differ in mechanism of action, dosing schedule, administration route, approved indications, and safety profiles. Your prescriber will help determine which medication is most appropriate for your specific condition, health history, and insurance coverage. BiologicHealthPlus carries both — contact us to check your eligibility for savings programs for either medication.
Xeljanz and Humira are both used in autoimmune or inflammatory conditions but differ in mechanism of action, dosing schedule, administration route, approved indications, and safety profiles. Your prescriber will help determine which medication is most appropriate for your specific condition, health history, and insurance coverage. BiologicHealthPlus carries both — contact us to check your eligibility for savings programs for either medication.
Xeljanz and Enbrel are both used in autoimmune or inflammatory conditions but differ in mechanism of action, dosing schedule, administration route, approved indications, and safety profiles. Your prescriber will help determine which medication is most appropriate for your specific condition, health history, and insurance coverage. BiologicHealthPlus carries both — contact us to check your eligibility for savings programs for either medication.
Xeljanz and Orencia are both used in autoimmune or inflammatory conditions but differ in mechanism of action, dosing schedule, administration route, approved indications, and safety profiles. Your prescriber will help determine which medication is most appropriate for your specific condition, health history, and insurance coverage. BiologicHealthPlus carries both — contact us to check your eligibility for savings programs for either medication.
Xeljanz and Actemra are both used in autoimmune or inflammatory conditions but differ in mechanism of action, dosing schedule, administration route, approved indications, and safety profiles. Your prescriber will help determine which medication is most appropriate for your specific condition, health history, and insurance coverage. BiologicHealthPlus carries both — contact us to check your eligibility for savings programs for either medication.
Xeljanz and Kevzara are both used in autoimmune or inflammatory conditions but differ in mechanism of action, dosing schedule, administration route, approved indications, and safety profiles. Your prescriber will help determine which medication is most appropriate for your specific condition, health history, and insurance coverage. BiologicHealthPlus carries both — contact us to check your eligibility for savings programs for either medication.
Xeljanz and Entyvio are both used in autoimmune or inflammatory conditions but differ in mechanism of action, dosing schedule, administration route, approved indications, and safety profiles. Your prescriber will help determine which medication is most appropriate for your specific condition, health history, and insurance coverage. BiologicHealthPlus carries both — contact us to check your eligibility for savings programs for either medication.
Lifestyle While Taking Xeljanz
Moderate alcohol consumption is not specifically prohibited with Xeljanz, but alcohol can affect your immune system and overall health. Discuss your habits with your healthcare provider for personalized guidance.
Many patients continue regular exercise while taking Xeljanz. Staying physically active can support overall health and may complement your treatment. Ask your provider about any specific activity restrictions for your condition.
If you miss a dose, contact your healthcare provider or pharmacist for guidance. Do not double your next dose without medical advice. BiologicHealthPlus pharmacists are available 24/7 to assist you.
Some medications may interact with Xeljanz. Always tell your prescriber and pharmacist about all medications, supplements, vitamins, and herbal products you take. BiologicHealthPlus reviews your medication list for potential interactions as part of our pharmacy services.
Related Resources
🔗 Condition Guides for Xeljanz
Rheumatoid Arthritis · Psoriatic Arthritis · Ulcerative Colitis · Ankylosing Spondylitis
Medical Disclaimer: This page is for informational purposes only and does not constitute medical advice. Dosage information and approved indications are subject to change. Always consult your prescribing physician or pharmacist before making any treatment decisions. BiologicHealthPlus is a licensed specialty pharmacy — not a medical practice. Last reviewed: July 2026 by the BiologicHealthPlus Clinical Team.