Cold-Chain Delivery for Biologic Medications
How temperature-controlled shipping works — and why it matters for your treatment
Key Takeaways
- Most biologics must be stored and shipped at 36°F–46°F (2°C–8°C)
- Exposure to heat, freezing, or light can inactivate a biologic
- BiologicHealthPlus ships in medical-grade insulated packaging with refrigerant packs
- Delivery is free to all 50 US states via overnight or 2-day express
- A temperature excursion does not automatically mean your medication is ruined — contact us immediately
Why Cold-Chain Matters
Biologic medications are large protein molecules that are sensitive to temperature, light, and physical stress. When a biologic is exposed to temperatures outside the recommended range — whether too hot or too cold (freezing) — the protein structure can degrade. A degraded biologic may be less effective or could trigger an immune response.
This is why proper cold-chain storage and shipping is critical — not just a convenience, but a medical necessity for ensuring your biologic works as intended.
Temperature Requirements by Medication
| Medication | Required Storage | Room Temp Limit |
|---|---|---|
| Humira | 36°F–46°F | 14 days up to 77°F |
| Skyrizi | 36°F–46°F | 14 days up to 77°F |
| Cosentyx | 36°F–46°F | 4 days up to 86°F |
| Dupixent | 36°F–46°F | 14 days up to 77°F |
| Tremfya | 36°F–46°F | 8 weeks up to 77°F |
| Rinvoq | Room temperature | Store at 59°F–86°F |
| Sotyktu | Room temperature | Store at 68°F–77°F |
🚚 Free Cold-Chain Delivery to All 50 States
BiologicHealthPlus ships all biologic medications in medical-grade temperature-controlled packaging. Delivery is free, tracked, and guaranteed safe.
Learn About Our Delivery →📚 Sources & Further Reading
Content developed with reference to leading health organizations, peer-reviewed research, and FDA prescribing information.
Medical Disclaimer: Educational content reviewed by the BiologicHealthPlus Clinical Team. Consult your healthcare provider for personalized advice. Last reviewed: August 2026.